Drug X has a median lethal dose of 30 mg and a median effective dose of 10. Drug Y has a therapeutic index of 4, while drug Z has a therapeutic index of 3. Which statement is accurate based on this information?
1. Drugs X and Y are safer than drug Z.
2. The therapeutic index of drug X is 20.
3. Drug Y is the safest of the three.
4. Drug Z is the safest of the three.
3
Rationale 1: Drugs X and Z have the same therapeutic index and are more dangerous than drug Y.
Rationale 2: The therapeutic index of drug X is 30/10 or 3.
Rationale 3: Since drug Y has the highest therapeutic index, it is the safest drug.
Rationale 4: Drugs X and Z have the same therapeutic index and are more dangerous than drug Y.
Global Rationale: Since drug Y has the highest therapeutic index, it is the safest drug. Drugs X and Z have the same therapeutic index and are more dangerous than drug Y. The therapeutic index of drug X is 30/10 or 3.
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