There are many factors that influence the decision to use a specific drug regimen. Consideration of which of the following factors includes evaluating the drug's therapeutic index?
a. Safety
b. Tolerability
c. Efficacy
d. Price
e. Simplicity of use
ANS: B
There are a multitude of factors that influence the decision to use a particular drug regimen. Preskorn's "STEPS" mnemonic helps to organize drug information by level of importance:
Sâ€"Safety
Tâ€"Tolerability
Eâ€"Efficacy
Pâ€"Price
Sâ€"Simplicity of use
The drug variables affecting patient tolerance to a drug include (1) the drug's potency; (2) the therapeutic index, or the ratio of effective dose to lethal dose; (3) maximum effect, the greatest response possible regardless of the dose given; (4) latency, the time necessary for the onset of therapeutic effects; (5) peak, the time it takes for drug effects to reach maximum; and (6) dura-tion of action, the length of time the drug is effective.
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