The distribution of a drug in the body is affected by
a. Dehydration
b. Decreased plasma protein levels
c. Decreased blood flow
d. All of the above
D
As people age, changes in the cardiovascular system may lead to decreased blood flow to specific target tissue and decreased drug distribution (response C). A lower blood volume, resulting from dehydration (response A), also decreases drug distribution. Decreased plasma protein levels found in many older adults may lead to less of the drug being bound to protein and more drug free to exert its actions (sometimes causing what would be considered a normal dose to be an overdose of a specific drug such as warfarin).
You might also like to view...
A 150-pound man is to receive a medication based on mg/kg. He is to receive 1 mg/kg. The nurse should give:
a. 50 mg. b. 68 mg. c. 75 mg. d. 80 mg.
The nurse is concerned that a client is at risk for developing a mental illness. What did the nurse assess to come to this conclusion? (Select all that apply.)
1. Does not sleep most nights 2. Unemployed for over 2 years 3. Meets with best friend once a week 4. Mother diagnosed with bipolar disorder 5. Smokes cigarettes and drinks alcohol every day
A client who experiences a mood disorder asks the nurse how antidepressants work to restore mood balance. The nurse should tell the client that:
1. medications induce happiness. 2. neurotransmitter function is restored. 3. medications restore oxygen to the brain. 4. medication enhances brainstem functioning.
Using silence is a nonverbal communication technique. Silence allows which of the following to occur in the conversation?
A) The unwillingness to continue listening B) The nurse to stop the conversation C) The ability of the client to ignore the nurse D) The regain of control in the conversation