Which of the following statements about apoptosis is true?
(a) Cells that constitutively express Bcl2 will be more prone to undergo apoptosis.
(b) The prodomain of procaspases contains the catalytic activity necessary for procaspase activation.
(c) Bax and Bak promote apoptosis by binding to procaspases in the apoptosome.
(d) Apoptosis is promoted by the release of cytochrome c into the cytosol from mitochondria.
Choice (d) is correct. Bcl2 tends to inhibit rather than promote apoptosis [choice (a)]. The prodomain of procaspases does not contain the catalytic activity needed for procaspase activation and is usually discarded from the active caspase [choice (b)]. When activated, Bax and Bak promote apoptosis by stimulating the release of cytochrome c from mitochondria into the cytosol, not by binding to procaspases in the apoptosome [choice (c)].
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The growth curve follows which phase pattern?
A. Lag B. Exponential C. Stationary D. Death