As an initial step in treating a client with angina, the physician prescribes nitroglycerin tablets, 0.3mg given sublingually. This drug's principle effects are produced by:
a. Antispasmotic effect on the pericardium
b. Causing an increased mycocardial oxygen demand
c. Vasodilation of peripheral vasculature
d. Improved conductivity in the myocardium
Ans: c. Vasodilation of peripheral vasculature
Nitroglycerin produces peripheral vasodilation, which reduces myocardial oxygen consumption and demand. Vasodilation in coronary arteries and collateral vessels may also increase blood flow to the ischemic areas of the heart. Nitroglycerin decreases myocardial oxygen demand. Nitroglycerin does not have an effect on pericardial spasticity or conductivity in the myocardium.
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