Drugs that alter the availability of norepinephrine and serotonin are not clinically effective in the treatment of depression for several weeks. Which of the following does this finding suggest?
A. These neurotransmitters are not involved in depression.
B. It is overactivity of these neurotransmitters that underlies depression, not underactivity.
C. The effectiveness of antidepressants is a placebo effect, as opposed to the result of a biochemical manipulation.
D. Changes in neurotransmitter function, as opposed to neurotransmitter level, cause depression.
Answer: D
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