The block in the stage of lymphocyte development described in questions 1-3 will be caused by a mutation in which of the genes listed (A-F)?
A. RAG-2
B. Ikaros
?. ?5 surrogate light chain
D. CD3?
E. TAP-1
F. Jak3
Stem cell to committed B or T lineage precursor
ANS: B. Ikaros is a transcription factor required for transition of a pluripotential stem cell to a cell committed to either B or T lymphocyte lineages.
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