A 25-year-old woman sees her doctor because of hirsutism (inappropriate hair growth) and excessive acne
At examination, her blood pressure is 150/90 mm Hg (elevated). Blood work reveals normal Na+ but low/normal K+ levels. Testosterone and dihydrotestosterone (DHT) levels are in the high end of the normal range, and DHEAS and ACTH are moderately elevated. Her physician suspects late-onset congenital adrenal hyperplasia due to subnormal activity of an adrenal enzyme.
The subnormal activity of which enzyme explains both the elevated adrenal androgens (e.g., DHEAS) AND hypertension (elevated blood pressure)?
A. CYP11B1
B. CYP17
C. CYP21A2
D. CYP11B2
E. CYP11A1
ANS: A
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