Which of the following can influence a patient's response to drug therapy? Select all that apply
a. Body weight
b. Genetics
c. Body rhythms
d. Psychosocial considerations
e. Smoking and/or alcohol intake
f. Bioavailability
g. Dosage
h. Literacy level of patient
ANS: A, B, C, D, E, F, G
In addition to pharmacokinetic and pharmacodynamic variables, there are variables that influence a patient's response to drug therapy. The variables include general state of health, life-span con-siderations, body weight, sex and genetics, body rhythms, psychosocial considerations, dietary considerations, smoking and alcohol intake, environment, drug additives and bioavailability, dosage and number of drugs administered, and the administration routes and techniques. Alt-hough the patient's literacy level and psychiatric history may influence his or her adherence to the medication regimen, there is no evidence that these factors will actually affect physical response to drug therapy.
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