Which of the following red cell inclusions is or are often found in lead poisoning?
a. Howell-Jolly bodies
b. Basophilic stippling
c. Heinz bodies
d. Cabot rings
ANS: B
Basophilic stippling, sometimes quite coarse, is characteristic of lead poisoning. Lead interferes with the breakdown of pyrimidine 5ยข-nucleotides, which in turn are believed to retard the breakdown of ribosomal ribonucleic acid (RNA), thus leading to stippling.
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