Types II and III hypersensitivities are both caused by IgG or IgM antibodies. Explain
how they are different.
What will be an ideal response
In type II hypersensitivities antibodies attach to the subject's cells and cause destruction of those cells via
complement lysis, accelerated phagocytosis, and/or NK cell lysis. In type III hypersensitivities the IgM or IgG
antibodies attach to soluble antigens and form circulating immune complexes. These immune complexes are
capable of depositing onto tissues, and if they activate complement, the tissues are destroyed.
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Fill in the blank(s) with the appropriate word(s).
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