What causes the degranulation of mast cells in asthma patients?
a. Antigens attaching to IgE molecules on the mast cell surface.
b. Antigens attaching to proteins receptors on mast cell surface.
c. Irritant receptors on the mast cells are stimulated by antigens.
d. Infectious particles attacking the mast cells.
ANS: A
When a patient with asthma inhales an allergen to which he or she is sensitized, the antigen cross-links to specific IgE molecules attached to the surface of mast cells in the bronchial mucosa and submucosa. The mast cells degranulate rapidly (within 30 min), releasing multiple mediators including leukotrienes (previously known as slow-reacting substance of anaphylaxis [SRS-A]), histamine, prostaglandins, platelet-activating factor, and other mediators.
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