A premenopausal woman has ER-positive breast cancer, and her prescriber has ordered tamoxifen [Nolvadex]. She asks the nurse if anastrozole [Arimidex] would work better for her. What will the nurse tell her?
a. Anastrozole is more likely to cause hot flushes than tamoxifen.
b. Anastrozole is more likely to promote endometrial carcinoma.
c. Cancer recurrence is higher with anastro-zole.
d. Until she is postmenopausal, anastrozole will not be effective.
D
Anastrozole is used to treat ER-positive breast cancer in postmenopausal women. Because it does not block estrogen production in the ovaries, it is not effective in premenopausal women. It may cause hot flushes but is less likely to do so than tamoxifen. It is devoid of all estrogenic activity and does not promote endometrial cancer
You might also like to view...
A 20-year-old female has been brought to the emergency department from a rave party where she collapsed on the dance floor. Her accompanying friends acknowledge that the woman took ecstasy early in the evening
Her heart rate is regular at 89 beats/minute and temperature 39.8 °C (103.6 °F) orally. The emergency team would recognize that which of the following phenomena, related to the drug, is a likely contributor to the woman's status? A) Increased peripheral vasoconstriction B) The direct pyrogenic effect of ecstasy C) The initiation of an inappropriate immune response D) Impaired temperature regulation by the hypothalamus
At the end of the shift, nurses document the care provided each of the clients. The time spent on this type of accounting activity would be considered which of the following?
a. Direct care c. Indirect care b. Productive time d. Nonproductive time
A child is 3.5 years old and weighs 36 pounds. Using Fried's rule, determine the necessary dose of drug Y that is routinely ordered for adults as 2 teaspoons every 4 hours.
A. 2.4 ml B. 2.6 ml C. 2.2 ml D. 2.8 ml
____________________ may be placed on the legs after surgery to prevent blood clots.
Fill in the blank(s) with the appropriate word(s).