Cyclosporine (Sandimmune) and tacrolimus (Prograf) represent which category of immunosuppressants?
1. Calcineurin inhibitors
2. Glucocorticoids
3. Antimetabolites
4. Antibodies
Correct Answer: 1
Rationale 1: Cyclosporine and tacrolimus are calcineurin inhibitors.
Rationale 2: Cyclosporine and tacrolimus are not glucocorticoids.
Rationale 3: Cyclosporine and tacrolimus are not antimetabolites.
Rationale 4: Cyclosporine and tacrolimus are not antibodies.
Global Rationale: Two of the most important drugs in transplant medicine, cyclosporine (Sandimmune, Neoral) and tacrolimus (Prograf), are calcineurin inhibitors. These drugs revolutionized the pharmacotherapy of transplant rejection and have been the mainstay of transplant therapy since the 1980s. They are not members of the other classes.
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