Paroxysmal nocturnal hemoglobinuria is:
a. Inherited as an X-linked recessive trait
b. Acquired as a clonal disorder
c. Inherited as an autosomal dominant disorder
d. Acquired after a viral infection
ANS: B
Paroxysmal nocturnal hemoglobinuria is an acquired disorder that can be shown to be clonal in nature. Some patients have two populations of red cells: (1) normal and (2) defective.
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