Which statement is accurate regarding medications that end up being secreted in bile?
1. All medications secreted in bile are excreted in the feces.
2. Some medications are excreted in the feces while others can be recirculated to the liver many times.
3. Most medications secreted in bile are metabolized in the gallbladder.
4. Generally, medications are not secreted in the bile.
2
Rationale 1: Some bile (and medications within) is excreted in the feces.
Rationale 2: Most bile is circulated back to the liver by enterohepatic circulation, where medications are metabolized in the liver.
Rationale 3: Medications are not metabolized in the gallbladder.
Rationale 4: Some medications are secreted in bile.
Global Rationale: Most bile is circulated back to the liver by enterohepatic circulation, where medications are metabolized in the liver. Some bile (and medications within) is excreted in the feces. Medications are not metabolized in the gallbladder.
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