After administering propylthiouracil (PTU), what effect would the nurse anticipate the drug will have in the patient's body?
A) To destroy part of the thyroid gland
B) To inhibit production of thyroid hormone in the thyroid gland
C) To suppress the anterior pituitary gland's secretion of thyroid-stimulating hormone (TSH)
D) To suppress the hypothalamus's production of thyrotropin-releasing hormone (TRH)
B
Feedback:
PTU is a thioamide that acts by lowering thyroid hormone levels by preventing the formation of thyroid hormone in the thyroid cells, which lowers the serum levels of thyroid hormone. They also partially inhibit the conversion of thyroxine to triiodothyronine at the cellular level. Iodine solutions oversaturate thyroid cells and top production of thyroid hormone. Radioactive iodine destroys part of the thyroid gland. PTU does not impact production or secretion of TSH or TRH.
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