What is the method of action for amiodarone?
Ans:
(it is a class 3 antiarrhythmic drug)
• Related structurally to thyroxine (contains iodine)
• Complex MOA showing Class I, II and III (& some IV) effects
• Dominant effect = K+ channel blockade.
• Decreases AV conduction & sinus node function.
• Blocks mostly inactivated Na+ channels
• Weak Ca2+ channel blocker
• Inhibits adrenergic stimulation (? & B-blocking properties)
• Antianginal & antiarrhythmic activit
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