Fred, a lipid-soluble drug molecule, has just been swallowed by a human. Trace Fred's likely routes through the body and describe what is likely to happen to Fred by the time he leaves the humans' body
What will be an ideal response?
Before being absorbed from the GI tract into the blood stream, Fred may be metabolized into a different molecule. Once into the blood stream of the portal system, Fred would have to pass through the liver, where he could also be metabolized, before entering the general circulatory system. Once in the general circulatory system, Fred would likely travel to various tissues, and if sufficiently lipid soluble pass into and out of the brain. At some point Fred would likely be metabolized into a water soluble (ionized) molecule, pass in to the kidneys and the urine, where he would be excreted. Fred could still be lipid soluble and get dumped into the bile ducts, where he would get deposited into the feces, where he could be excreted.
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a. girls are more sensitive. b. boys can control their feelings with greater ease. c. as early as the preschool period, parents talk more with daughters than with sons about emotions. d. females have deeper emotions.