Both aspirin and ibuprofen products inhibit which process in the body?
1. Histamine production
2. Platelet production
3. Cytokine IL-1 synthesis
4. Cyclooxygenase (COX) synthesis
Correct Answer: 4
Rationale 1: Neither aspirin nor ibuprofen products inhibit the production of histamines in response to the inflammatory process.
Rationale 2: Neither aspirin nor ibuprofen products inhibit platelet production. Both, however, inhibit platelet aggregation.
Rationale 3: Cytokine IL-1 is produced during the inflammatory process. Macrophages, with the processed antigens, combine with cytokine IL-1 to stimulate the helper T cells.
Rationale 4: Aspirin blocks the synthesis of prostaglandins by inhibiting the enzyme cyclooxygenase (COX). Aspirin and the ibuprofen-like NSAIDs block both forms of the enzyme, cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), by changing their structures and preventing the formation of prostaglandins.
Global Rationale: The anti-inflammatory action of aspirin is caused by the inhibition of COX-1 and COX-2 that leads to reduced prostaglandin synthesis. Ibuprofen and ibuprofen-like drugs all inhibit both COX-1 and COX-2 when used at recommended doses. Neither inhibits platelet production, histamine production, or cytokine IL-1 synthesis.
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