Why is dextrose 5% in water considered to be a hypotonic solution rather than an isotonic solution, even though its osmolarity is 272 mOsm/L?
A. An isotonic solution must have an osmolarity greater than 300 mOsm/L.
B. Glucose is not an electrolyte and does not completely dissociate in water.
C. Glucose is immediately metabolized upon administration, leaving pure water in circulation.
D. Intravenous glucose immediately draws water from the interstitial and intracellu-lar spaces, resulting in hemodilution.
C
Dextrose 5% in water is isotonic in its container but, upon reaching the blood, glucose is taken up by cells for metabolism (in the nondiabetic client) as rapidly as it is infused, with the remainder of the infused fluid being water.
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