What is the physiological action of tricyclic antidepressants (TCAs)?
A) Inhibiting monoamine oxidase inhibitors that break down norepinephrine
B) Inhibiting nerve activity, which prevents over excitability or stimulation
C) Blocking the reuptake of serotonin, which increases the levels of norepinephrine
D) Inhibiting reuptake of norepinephrine and serotonin
D
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TCAs inhibit presynaptic reuptake of norepinephrine and serotonin, which cause an accumulation of the neurotransmitters that is thought to create the antidepressant effect. Monoamine oxidase inhibitors irreversibly inhibit monoamine oxidase that breaks down norepinephrine and serotonin. Selective serotonin reuptake inhibitors block the reuptake of serotonin; gamma-aminobutyric acid inhibits nerve activity.
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