A tuberculosis antibiotic, discovered in the 1950s, prevents the reduction of NAD+ in the bacteria causing the infection. Determine the effect of this medication on ATP production during glycolysis
What will be an ideal response?
No ATP would be generated in glycolysis if NAD+ cannot be reduced when this antibiotic is present. NAD+, an electron carrier, is the first to accept electrons from nutrients during catabolism. During glucose catabolism, the monosaccharide glucose is broken down and the chemical energy in its bonds is used to drive ATP synthesis. Glycolysis is one of the two main parts of glucose catabolism. During glycolysis, two molecules of NADH are synthesized and glucose is split into two three-carbon pyruvate molecules. As pyruvate is reduced, NADH is oxidized to NAD+. This reaction is critical because it regenerates NAD+, which is needed to oxidize glyceraldehyde-3-phosphate to 1, 3-bisphosphoglycerate in the energy payoff phase. Without this NAD+, no ATP would be generated in glycolysis at all.
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Indicate whether the statement is true or false
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