G protein coupled receptors are a large class of receptors that bind hormones as well as other signaling molecules, neurotransmitters, and even odorants. They are a major target of pharmaceutical drugs for various disorders. Typically, the drug acts as an antagonist, blocking the binding site on the GPCR. Why is the receptor a more attractive drug target than the G protein activated downstream? (Check all that apply.)

Question

_____ It is easier to target molecules from the outside of the cell membrane, because getting drugs into the cell can be difficult.
_____ Interfering with the G protein would require getting a drug across several membranes into the cell's nucleus.
_____ The "G-protein" is not really a protein but just a GTP molecules, which is too small to be a possible drug target.
_____ Since GPCRs are so widespread and perform many roles in the body, targeting G proteins used by multiple GPCRs would create side-effects beyond the targeted physiological function.
_____ Since the GPCRs bind a variety of unique ligands, their structures are varied enough to be able to create specific targeted drugs for certain pathways.
_____ It is easier to target molecules from the outside of the cell membrane, because getting drugs into the cell can be difficult.
_____ The "G-protein" is not really a protein but just a GTP molecules, which is too small to be a possible drug target.

Answer 1

__X__ It is easier to target molecules from the outside of the cell membrane, because getting drugs into the cell can be difficult.
_____ Interfering with the G protein would require getting a drug across several membranes into the cell's nucleus.
_____ The "G-protein" is not really a protein but just a GTP molecules, which is too small to be a possible drug target.
__X__ Since GPCRs are so widespread and perform many roles in the body, targeting G proteins used by multiple GPCRs would create side-effects beyond the targeted physiological function.
__X__ Since the GPCRs bind a variety of unique ligands, their structures are varied enough to be able to create specific targeted drugs for certain pathways.
__X__ It is easier to target molecules from the outside of the cell membrane, because getting drugs into the cell can be difficult.
_____ The "G-protein" is not really a protein but just a GTP molecules, which is too small to be a possible drug target.