c-Met is an oncogene that contributes to the development of certain cancers by triggering cell division and tumor growth. In a 2009 article, Yan and colleagues found regions in the 3' untranslated region of c-Met mRNA complementary to microRNA-1/206. In addition, higher levels of microRNA-1/206 were associated with slower cell proliferation. What is a likely explanation for the inverse correlation between microRNA-1/206 and cell proliferation?

A. MicroRNA-1/206 codes for a protein that directly binds to and inhibits c-Met protein.
B. MicroRNA-1/206 targets c-Met mRNA for destruction via RISC.
C. MicroRNA-1/206 stabilizes c-Met mRNA, leading to enhanced translation.
D. MicroRNA-1/206 codes for a tumor suppressor protein that directly inhibits cell proliferation.


Ans: B. MicroRNA-1/206 targets c-Met mRNA for destruction via RISC.

Biology & Microbiology

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