A client with AIDS is suffering from a systemic fungal infection. The nurse anticipates that the drug of choice for this client will be:
1. fluconazole.
2. amphotericin B.
3. nystatin.
4. griseofulvin.
Correct Answer: 2
Rationale 1: Fluconazole is for simple fungal infections.
Rationale 2: The drug of choice for these disorders is amphotericin B.
Rationale 3: Nystatin is for simple fungal infections such as Candida.
Rationale 4: Griseofulvin is for superficial fungal infections.
Global Rationale: The AIDS epidemic, however, resulted in the frequent clinical occurrence of previously rare mycoses, such as cryptococcosis and coccidioidomycosis. Pharmacologic options for serious systemic mycoses are limited. Amphotericin B (Fungizone) has been the traditional drug of choice for systemic fungal infections since the 1960s. Fluconazole is for simple fungal infections. Nystatin is for simple fungal infections such as Candida. Griseofulvin is for superficial fungal infections.
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