A nurse is discussing phentolamine [OraVerse] with a nursing student. Which statement by the student indicates the need for further teaching?
a. "Phentolamine can be used to block both epinephrine- and norepinephrine-mediated vasoconstriction."
b. "Phentolamine can be used to prevent tis-sue necrosis after extravasation of drugs such as norepinephrine."
c. "Phentolamine is a competitive adrenergic agonist that acts selectively on alpha1 re-ceptors."
d. "Side effects of phentolamine may include tachycardia and hypotension."
C
Phentolamine has actions on both alpha1 and alpha2 receptors; it is not selective for alpha1 re-ceptors only. It blocks both epinephrine- and norepinephrine-mediated vasoconstriction. It is used to prevent tissue necrosis after extravasation of drugs such as norepinephrine and other drugs that produce alpha1-mediated vasoconstriction. Side effects include tachycardia and hypo-tension.
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