A patient diagnosed with intermittent claudication will be discharged to home on cilostazol (Pletal). Which of the following statements made by the patient indicates a need for further discharge instruction?
a. "I will take the cilostazol with grapefruit juice."
b. "Headache may be a side effect of the cilostazol."
c. "I will take the cilostazol 30 minutes before breakfast and 30 minutes before dinner."
d. "I should expect less pain and cramping in my legs when walking."
ANS: A
Cilostazol levels can be increased by grapefruit juice.
Headache is the most common adverse effect of cilostazol (34%).
The usual dosage of cilostazol is 100 mg twice daily, taken 30 minutes before or 2 hours after breakfast and the evening meal.
Because cilostazol promotes vasodilation by inhibiting PDE3 in blood vessels, the patient will have less pain and cramping during activity.
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