A patient has a Pseudomonas aeruginosa infection that is sensitive to aminoglycosides, and the prescriber orders gentamicin
The patient tells the nurse that a friend received amikacin [Amikin] for a similar infection and wonders why amikacin was not ordered. What will the nurse tell the patient? a. "Amikacin is given when infectious agents are resistant to other aminoglycosides."
b. "Amikacin is more vulnerable to inactiva-tion by bacterial enzymes."
c. "Amikacin is a narrow-spectrum drug and will probably not work for this infection."
d. "Gentamicin is less toxic to the ears and the kidneys."
A
Resistance to amikacin is uncommon at this point; to minimize the emergence of amika-cin-resistant bacteria, this drug is reserved for infections in which resistance to other aminogly-cosides has developed. Amikacin is the least susceptible to inactivation by bacterial enzymes. Amikacin is a broad-spectrum antibiotic. All aminoglycosides are ototoxic and nephrotoxic.
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