When an individual drinks regularly, how does this affect his/her liver function?
Frequent and chronic alcohol consumption can interfere with normal liver function partly because the two main by-products of alcohol metabolism are acetaldehyde and NADH + H+. The accumulation of acetaldehyde damages the liver, impairing its function. Alcohol metabolism also raises NADH + H+ levels and lowers NAD+ levels in the liver. As a result, the activity of numerous NAD-linked enzymes becomes limited. With limited NAD+, pyruvate is instead converted to lactate.
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