What causes the pain in post-herpetic neuralgia, diabetic neuropathy, and Guillain-Barré syndrome?
A. Psychological abnormalities
B. Ectopic foci
C. Central nervous system response to small fiber deafferentation
D. Pain matrix dysfunction
E. Reduced activity in pain inhibition areas of the cerebral cortex
ANS: C
Rationale: Post-herpetic neuralgia, diabetic neuropathy, and Guillain-Barré syndrome all cause small fiber deafferentation, and the central nervous system response to the deafferentation causes the pain.
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