A patient has developed urticaria following the administration of an oral antibiotic. What substance most commonly mediates the formation of the wheals that characterize urticaria?
A) Cytokines
B) CD4+ lymphocytes
C) Histamine
D) Interleukin
C
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Histamine is the most common mediator of urticaria; it causes vasodilation, increased vascular permeability, and pruritus. Cytokines, including interleukin, and CD4+ lymphocytes do not usually mediate the development of urticaria.
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