A client is being treated in the emergency department for an anaphylactic reaction to an antibiotic. The client will be receiving an antihistamine in addition to other preparations. Which drug would the nurse anticipate administering?
1. Fexofenadine (Allegra)
2. Azelastine (Astelin)
3. Loratadine (Claritin)
4. Diphenhydramine (Benadryl)
Correct Answer: 4
Rationale 1: Fexofenadine is not appropriate for use in an emergency.
Rationale 2: Azelastine is not appropriate for use in an emergency.
Rationale 3: Loratadine is not appropriate for use in an emergency.
Rationale 4: Benadryl (diphenhydramine) is the preparation most likely to be used, as it can be administered by intravenous route.
Global Rationale: Antihistamines are used as adjuncts to the emergency treatment of anaphylaxis, which is the most severe form of allergic reaction. Fexofenadine and loratadine are available only in oral forms, so are not appropriate for emergency use. Azelastine is available in a nasal mist, but this route is not useful in an emergency situation. Diphenhydramine is available in an intravenous preparation which makes emergency use possible.
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