A client has a surgical wound infection. The nurse recognizes that a healthy body will respond by rapidly increasing colony-stimulating factors (CSFs) in the blood. How does this increase help in fighting the infection?
1. Slowed migration of leukocytes
2. Elevated level of serum antibodies
3. Increased phagocytosis
4. Decreased antibody toxicity
Correct Answer: 3
Rationale 1: Migration of leukocytes is generally enhanced when active infection is present.
Rationale 2: Colony-stimulating factors can elevate serum antibody levels. That reaction is not relevant in fighting an active wound infection.
Rationale 3: White cell phagocytosis is increased by CSFs and is necessary because of a heavy load of bacteria in the wound.
Rationale 4: Increased levels of CFS increase antibody toxicity.
Global Rationale: White cell phagocytosis is increased by CSFs and is necessary because of a heavy load of bacteria in the wound. Migration of leukocytes is generally enhanced when active infection is present. Colony-stimulating factors can elevate serum antibody levels. That reaction is not relevant in fighting an active wound infection. Increased levels of CFS increase antibody toxicity.
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