Using your knowledge of the mechanism of action of the bisphosphonates, select the true statement related to their use in the treatment of osteoporosis.

A. It is advisable not to take the bisphosphonates within 2 hours of taking calcium supplements, caffeine, or antacids because absorption will be increased.
B. It is advisable not to take the bisphosphonates within 1 hour of taking calcium supplements, caffeine, or antacids because absorption will be decreased.
C. It is advisable not to take the bisphosphonates within 2 hours of taking calcium supplements, caffeine, or antacids because absorption will be decreased.
D. It is advisable not to take the bisphosphonates within 1 hour of taking calcium supplements, caffeine, or antacids because absorption will be increased.


Answer: B

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