According to the Bohr effect, when the pH drops, what happens? 1. The affinity of Hb for O2 decreases. 2. The Hb saturation for a given PO2 falls. 3. The Hb saturation for a given PO2 rises
a. 1 and 2 only
b. 2 only
c. 2 and 3 only
d. 1, 2, and 3
ANS: A
The impact of changes in blood pH on hemoglobin affinity for O2 is called the Bohr effect. As shown in Figure 12-10, the Bohr effect alters the position of the HbO2 dissociation curve. A low pH (acidity) shifts the curve to the right, decreasing Hb affinity for O2 and thus O2 saturation.
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