After a liver biopsy, a patient is diagnosed with anaplasia of liver cells. What would be indicated for this patient's care?
1. monitoring for the development of cancer
2. chemotherapy for liver cancer
3. monitoring for the onset of diabetes mellitus
4. medication to reverse the anaplastic cells
Correct Answer: 1
Anaplasia is the regression of a cell to an immature or undifferentiated cell type. Anaplastic cell division is no longer under DNA control. Anaplasia usually occurs when a damaging or transforming event takes place inside the dividing, still undifferentiated cell, leading to loss of useful function. Anaplasia may occur in response to overwhelmingly destructive conditions inside the cell or in surrounding tissue. Anaplasia is not reversible, but the degree of anaplasia determines the potential risk for cancer. The patient will most likely need careful monitoring to ensure the cells do not develop into cancer. The patient does not have cancer and would not need chemotherapy at this time. Anaplastic cells of the pancreas would increase this patient's chances of developing diabetes mellitus. Anaplastic cells cannot be reversed.
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