Which statements indicate the nurse has a good understanding of the genetic influence on hyperlipidemia?
Note: Credit will be given only if all correct choices and no incorrect choices are selected.
Standard Text: Select all that apply.
1. "GWASs are not finding an association between gene variants and high LDL cholesterol."
2. "Up to 80% of the risk for high LDL levels may be genetically determined."
3. "SORT1 is associated with elevated LDL levels and coronary artery disease."
4. "No gene has been implicated in actual lethal disease state such as myocardial infarction."
5. "There is an LDLR variant that is associated with low LDL levels."
3,5
Rationale 1: In recent GWAS more than 100 genetic loci have been linked to hyperlipidemia.
Rationale 2: Currently the risk from genetic makeup is estimated to be about 25% to 30%.
Rationale 3: The gene SORT1 is associated not only with elevated LDL level, but also with coronary artery disease and myocardial infarction.
Rationale 4: The gene SORT1 has been associated with myocardial infarction.
Rationale 5: An LDLR variant was associated with low LDL cholesterol and a reduced risk of coronary artery disease.
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