For a particular gene, the frequency of the dominant allele H is 0.65. The total population size is

10,000 individuals. Also, the homozygous recessive condition results in living but sterile offspring.
Fill in the table of values for the generations indicated:Generation
p q p2 2pq q2
1
2
Does this population exhibit Hardy-Weinberg equilibrium? Why or why not? If not, what assumptions
does the Hardy-Weinberg principle make that appear to be inapplicable in this situation? What will be an ideal response?


Concepts to Consider: The Hardy-Weinberg equation allows students to calculate the value for q
(0.35) based on the frequency of H (= p). The values for the particular genotypes are then processed
mathematically (the last three columns of the table for generation 1 are 4,225 individuals; 4,550
individuals; 1,225 individuals). The values of p and q in the second generation are based on the fact
that the individuals with the recessive genotype (q2) are sterile and are therefore removed from the
reproductive population. The number of alleles in the population equals the number of surviving
offspring ? 2, or 17,610. Of these, 13,060 are dominant H alleles (the number of homozygous
dominant individuals ? 2 + the number of heterozygous individuals) and 4,550 are recessive h alleles.
This allows for the calculation of new values for p (0.74) and q (0.26) with associated changes in the
number of individuals with each genotype.

Biology & Microbiology

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