The nurse is caring for a client who has developed an infection that is resistant to fluoroquinolone therapy. The nurse knows that this resistance is due to which reasons?

Question

Standard Text: Select all that apply.
1. A mutation to the DNA gyrase.
2. The development of resistant pumps within the bacteria.
3. The bacterial cell wall structure has become impermeable.
4. Mutations to DNA helicase alter its ability to bind with fluoroquinolones.
5. The client administered the medication improperly.

Answer 1

Correct Answer: 1,2,3
Rationale 1: Mutations to DNA gyrase can alter its ability to bind fluoroquinolones, thus rendering the drug less effective.
Rationale 2: Some bacteria have developed resistance pumps that remove fluoroquinolones from inside their cells, thus rending the drug less effective.
Rationale 3: Some bacteria have developed a cell wall structure that is less permeable to the drugs, thus rendering the drug less effective.
Rationale 4: Mutations to DNA helicase have not rendered fluoroquinolones less effective.
Rationale 5: Improper administration of medication does not render the drug less effective.
Global Rationale: Mutations to DNA gyrase can alter its ability to bind fluoroquinolones, thus rendering the drug less effective. Some bacteria have developed resistance pumps that remove fluoroquinolones from inside their cells, thus rending the drug less effective. Some bacteria have developed a cell wall structure that is less permeable to the drugs, thus rendering the drug less effective. Mutations to DNA helicase have not rendered fluoroquinolones less effective. Improper administration of medication does not render the drug less effective.