Which statement made by the nurse regarding topical medications is the most appropriate when referring to the desired reaction?
1. The desired reaction is absorption of the medication into the circulation.
2. The desired reaction is a specified rate of delivery.
3. The desired reaction is fewer side effects.
4. The desired reaction is systemic absorption through the skin.
Correct Answer: 3
Rationale 1: Absorption of the medication into the circulation is incorrect because topical drugs intended to produce a local effect are absorbed very slowly and only small amounts reach the general circulation. Topical delivery also produces fewer side effects. Systemic absorption occurs with slow release and absorption into the general circulation to produce a systemic (systemwide) effect. Transdermal patches contain a specific amount of drug with a specific rate of delivery.
Rationale 2: A specified rate of delivery is incorrect because topical drugs intended to produce a local effect are absorbed very slowly and only small amounts reach the general circulation. Topical delivery also produces fewer side effects. Systemic absorption occurs with slow release and absorption into the general circulation to produce a systemic (systemwide) effect. Transdermal patches contain a specific amount of drug with a specific rate of delivery.
Rationale 3: Fewer side effects is one of the desired reaction of a topical drug.
Rationale 4: Systemic absorption through the skin is incorrect because topical drugs intended to produce a local effect are absorbed very slowly and only small amounts reach the general circulation. Topical delivery also produces fewer side effects. Systemic absorption occurs with slow release and absorption into the general circulation to produce a systemic (systemwide) effect. Transdermal patches contain a specific amount of drug with a specific rate of delivery.
Global Rationale: Fewer side effects is one of the desired reaction of a topical drug. Absorption of the medication into the circulation is incorrect because topical drugs intended to produce a local effect are absorbed very slowly and only small amounts reach the general circulation. A specified rate of delivery is incorrect because topical drugs intended to produce a local effect are absorbed very slowly and only small amounts reach the general circulation. Systemic absorption through the skin is incorrect because topical drugs intended to produce a local effect are absorbed very slowly and only small amounts reach the general circulation.
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