Describe how renin can ultimately increase the kidney's ability to conserve water in the distal tubule. Include the following in your answer : blood pressure, aldosterone, lungs, angiotensinogen, angiotensin I and II, and JGA
What will be an ideal response?
When blood pressure is low, the JGA secretes the enzyme renin, which converts angiotensinogen (a plasma protein) into angiotensin I, which is then converted into angiotensin II in the capillaries of the lungs. Angiotensin II causes the release of aldosterone from the adrenal cortex. Aldosterone causes cells in the distal tubule to insert more Na+ channels into the luminal membranes and more Na+-K+ pumps into the basolateral membranes of these cells. As a result, more Na+ ions are reabsorbed, allowing water to follow via osmosis, which means more water is conserved and less is excreted in the urine.
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