What receptors can it bind on the T cell and what signal does it deliver in each case?
What will be an ideal response?
When B7 binds to CD28, the B7 receptor expressed earliest on T cells, an activating signal is delivered and T cells undergo clonal expansion and differentiation. This interaction requires, of course, that the T-cell receptor and co-receptor are engaged specifically with a peptide:MHC molecule complex. The second B7 receptor, CTLA4, binds B7 with about 20-fold higher affinity than does CD28. An inhibitory signal is delivered to the T cell when B7 on the professional antigen-presenting cell binds to CTLA4. This mechanism serves to regulate T-cell proliferation and to suppress T-cell activation after an immune response.
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