Which of the following statements about over-the-counter (OTC) melatonin is accurate?
A)
It has received the FDA approval for effectiveness as a sleep aid.
B)
Long-term studies of melatonin conclude that it is nonaddicting.
C)
It produces phase-shifting changes in the circadian rhythm.
D)
Under strict clinical testing, potency and purity of melatonin have been shown to be consistent.
Ans:
C
Feedback:
Administration of melatonin produces phase-shifting changes in the circadian rhythm similar to those caused by light. Synthetic forms of melatonin are available without prescription in health food stores and pharmacies. However, synthetic forms of melatonin are not regulated by the FDA; therefore, their potency, purity, safety, and effectiveness cannot be ensured. There is a lack of clinical trial evidence about dosage, adverse effects, and drug interactions with over-the-counter forms of melatonin.
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