Aromatic amines found in the rubber industry enter the human body in the workplace and are converted into carcinogens in the liver. This conversion is mediated by
A. alanine aminotransferase
B. aspartate aminotransferase
C. alkaline phosphatase
D. cytochrome P450 oxygenase
E. DNAse
D
Cytochrome P450 is a group of enzymes that are essential for the metabolic conversion of many endogenous and exogenous substances in liver cells. These enzymes are involved in the conversion of some procarcinogens into proximate carcinogens. The carcinogens derived from the conversion of azo dyes in liver cells are released into the blood and reach the urinary bladder, where they cause urothelial neoplasia. Alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase belong to the clinically important enzymes forming the so-called liver function tests and are not involved in carcinogenesis. DNAse is an enzyme that degrades DNA and is not related to activation of carcinogens, which takes place in the microsomal fraction of the cytoplasm.
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