A biological theory to explain suicide may emerge from the finding in several studies that those who successfully commit suicide have:
a. atrophy of the brain on postmortem
b. serotonin in their bloodstream
c. abnormal electroencephalogram (EEG) readings
d. low 5-hydroxyindoleacetic acid (5-HIAA) in body fluids
D
A biological theory to explain suicide may emerge from findings in several studies that those who successfully commit suicide have low 5-hydroxyindoleacetic acid (5-HIAA) in body fluids. In general 5-HIAA levels in assayable body fluids are thought to reflect levels of brain serotonin, an important monoamine brain neurotransmitter. Serotonin is readily metabolized to 5-HIAA, which circulates in blood and cerebrospinal fluid. Multiple studies suggest that a subset of suicide attempters and completers, perhaps particularly those who use violent means of self-destruction, have very low 5-HIAA. This would support the possibility that there was a low level of serotonin in the brain.
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