Describe how rolling circle replication can generate multimers of replicated DNA
What will be an ideal response?
Ans: Rolling circle replication is replication of one strand of a circular duplex template DNA. One of the two strands is nicked and the free 3? end is used as a primer to begin replication; the 5? end of the nicked strand is displaced. Because the template strand is circular, replication can continue indefinitely, creating a multimeric single-stranded replication product.
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