Transcription factors generally "read" DNA sequences through amino acid–nucleotide contacts in the major groove because:

A. there are no minor groove hydrogen bond acceptors available at A–T base pairs.
B. the minor groove displays only methyl functional groups for recognition.
C. there are more hydrogen bond donors and acceptors in the major groove.
D. all minor groove functional groups are the same.


C

Biology & Microbiology

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