A 5-year-old male presents with low-set ears, a fish-shaped mouth, and involuntary rapid muscu-lar contraction. Laboratory testing reveals decreased calcium levels. Which of the following di-agnosis is most likely?
a. B-lymphocyte deficiency
b. T-lymphocyte deficiency
c. Combined immunologic deficiency
d. Complement deficiency
ANS: B
DiGeorge syndrome results in greatly decreased T cell numbers and function and is evidenced by abnormal development of facial features that are controlled by the same embryonic pouches; these include low-set ears, fish-shaped mouth, and other altered features. B-lymphocyte defi-ciency is not manifested by these symptoms. Neither combined immunologic deficiency nor complement deficiency is manifested by these symptoms.
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