A patient has been taking nalidixic acid (NegGram) for recurrent urinary tract infections. While reviewing the patient's medications, that nurse notes that the patient also has been taking warfarin (Coumadin) and alerts the prescriber
What change to the medication regimen would the nurse anticipate?
a. Increase in the warfarin
b. Decrease in the warfarin
c. Increase in the nalidixic acid
d. Decrease in the nalidixic acid
ANS: B
Nalidixic acid can intensify the effects of warfarin, and a reduction in the warfarin dosage may be needed.
Nalidix acid increases warfarin levels, thus it would be inappropriate to increase the dose.
Concurrent administration of nalidixic acid and warfarin does not affect nalidixic levels.
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